ARG58863
anti-GRK6 antibody
anti-GRK6 antibody for Western blot and Human,Mouse,Rat
Overview
Product Description | Rabbit Polyclonal antibody recognizes GRK6 |
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Tested Reactivity | Hu, Ms, Rat |
Tested Application | WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | GRK6 |
Antigen Species | Human |
Immunogen | Recombinant fusion protein corresponding to aa. 1-170 of Human GRK6 (NP_001004106.1). |
Conjugation | Un-conjugated |
Alternate Names | G protein-coupled receptor kinase GRK6; G protein-coupled receptor kinase 6; EC 2.7.11.16; GPRK6 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
Positive Control | Jurkat | ||||
Observed Size | 65 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # O70293 Mouse G protein-coupled receptor kinase 6 Swiss-port # P43250 Human G protein-coupled receptor kinase 6 |
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Gene Symbol | GRK6 |
Gene Full Name | G protein-coupled receptor kinase 6 |
Background | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
Function | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). [UniProt] |
Cellular Localization | Lipid-anchor, Membrane. [UniProt] |
Calculated MW | 66 kDa |
PTM | It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. [UniProt] |
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