ARG43511
anti-GRID2 antibody
anti-GRID2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GRID2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GRID2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to N-terminal region of human Somatostatin. |
| Conjugation | Un-conjugated |
| Alternate Names | GRID2; Glutamate Ionotropic Receptor Delta Type Subunit 2; GluD2; Glutamate Receptor, Ionotropic, Delta 2; Glutamate Receptor Ionotropic, Delta-2; GluR Delta-2 Subunit; GluR-Delta-2; Glutamate Receptor Delta-2 Subunit; SCAR18; GLURD2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 113 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.01% Sodium azide and 4% Trehalose. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GRID2 |
| Gene Full Name | Glutamate Ionotropic Receptor Delta Type Subunit 2 |
| Background | The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014] |
| Function | Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. [UniProt] |
| Cellular Localization | Cell membrane; Membrane; Postsynaptic cell membrane; Synapse. [UniProt] |
| Calculated MW | 113 kDa |
| PTM | Disulfide bond; Glycoprotein; Phosphoprotein. [UniProt] |
Images (5) Click the Picture to Zoom In
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ARG43511 anti-GRID2 antibody WB image
Western blot: HL-60 stained with ARG43511 anti-GRID2 antibody at 0.5 μg/ml dilution.
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ARG43511 anti-GRID2 antibody FACS image
Flow Cytometry: U20S stained with ARG43511 anti-GRID2 antibody at 1 µg/10^6 cells dilution.
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ARG43511 anti-GRID2 antibody WB image
Western blot: Rat brain stained with ARG43511 anti-GRID2 antibody at 0.5 μg/ml dilution.
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ARG43511 anti-GRID2 antibody FACS image
Flow Cytometry: C6 stained with ARG43511 anti-GRID2 antibody at 1 µg/10^6 cells dilution.
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ARG43511 anti-GRID2 antibody WB image
Western blot: Mouse brain stained with ARG43511 anti-GRID2 antibody at 0.5 μg/ml dilution.
