ARG58783
anti-GNS antibody
anti-GNS antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GNS |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GNS |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to W238-R355 of Human GNS. |
| Conjugation | Un-conjugated |
| Alternate Names | G6S; EC 3.1.6.14; Glucosamine-6-sulfatase; N-acetylglucosamine-6-sulfatase |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GNS |
| Gene Full Name | glucosamine (N-acetyl)-6-sulfatase |
| Background | The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. [provided by RefSeq, Jul 2008] |
| Cellular Localization | Lysosome. [UniProt] |
| Calculated MW | 62 kDa |
| PTM | The form A (78 kDa) is processed by internal peptidase cleavage to a 32 kDa N-terminal species (form B) and a 48 kDa C-terminal species. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG58783 anti-GNS antibody WB image
Western blot: 50 µg of samples under reducing conditions. HepG2, PANC-1 and SGC-7901 cell lysates stained with ARG58783 anti-GNS antibody at 0.5 µg/ml, overnight at 4°C.
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ARG58783 anti-GNS antibody WB image
Western blot: 50 µg of samples under reducing conditions. Rat lung, Rat kidney, Rat testis, PC-12, Mouse lung, Mouse kidney, Mouse testis, Mouse spleen and Mouse thymus lysates stained with ARG58783 anti-GNS antibody at 0.5 µg/ml, overnight at 4°C.
