ARG58922
anti-GNA11 antibody
anti-GNA11 antibody for ICC/IF,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GNA11 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GNA11 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 115-146 of Human GNA11. |
| Conjugation | Un-conjugated |
| Alternate Names | FHH2; GNA-11; Guanine nucleotide-binding protein G; Guanine nucleotide-binding protein subunit alpha-11; HHC2; G alpha-11; HYPOC2; y; G-protein subunit alpha-11; FBH; FBH2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | HeLa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide. |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P21278 Mouse Guanine nucleotide-binding protein subunit alpha-11 Swiss-port # P29992 Human Guanine nucleotide-binding protein subunit alpha-11 |
|---|---|
| Gene Symbol | GNA11 |
| Gene Full Name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
| Background | The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013] |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. [UniProt] |
| Cellular Localization | Cell membrane; Lipid-anchor. Cytoplasm. Note=In testicular cells, expressed exclusively in the cytoplasm. [UniProt] |
| Calculated MW | 42 kDa |
| PTM | (Microbial infection) Deamidated at Gln-209 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG58922 anti-GNA11 antibody ICC/IF image
Immunofluorescence: 4% Paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized NIH/3T3 cells stained with ARG58922 anti-GNA11 antibody (green) at 1:25 dilution. The nuclear counter stain is DAPI (blue).
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ARG58922 anti-GNA11 antibody WB image
Western blot: 20 µg of HeLa cell lysate stained with ARG58922 anti-GNA11 antibody at 1:2000 dilution.
