ARG58918

anti-GNA11 antibody

anti-GNA11 antibody for Western blot and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes GNA11
Tested Reactivity Hu
Predict Reactivity Ms, Rat, Bov, Pig
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name GNA11
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 1-30 of Human GNA11.
Conjugation Un-conjugated
Alternate Names FHH2; GNA-11; Guanine nucleotide-binding protein G; Guanine nucleotide-binding protein subunit alpha-11; HHC2; G alpha-11; HYPOC2; y; G-protein subunit alpha-11; FBH; FBH2

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control A2058

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide.
Preservative 0.09% (W/V) Sodium azide.
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 2767 Human GNA11

Swiss-port # P29992 Human Guanine nucleotide-binding protein subunit alpha-11

Gene Symbol GNA11
Gene Full Name guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Background The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. [UniProt]
Cellular Localization Cell membrane; Lipid-anchor. Cytoplasm. Note=In testicular cells, expressed exclusively in the cytoplasm. [UniProt]
Calculated MW 42 kDa
PTM (Microbial infection) Deamidated at Gln-209 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA. [UniProt]

Images (1) Click the Picture to Zoom In

  • ARG58918 anti-GNA11 antibody WB image

    Western blot: 35 µg of A2058 cell lysate stained with ARG58918 anti-GNA11 antibody.