ARG59122
anti-GLUT2 antibody
anti-GLUT2 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GLUT2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GLUT2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 486-514 of Human GLUT2. (ETKGKSFEEIAAEFQKKSGSAHRPKAAVE). |
| Conjugation | Un-conjugated |
| Alternate Names | Solute carrier family 2, facilitated glucose transporter member 2; GLUT-2; GLUT2; Glucose transporter type 2, liver |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: By heat mediation. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P11168 Human Solute carrier family 2, facilitated glucose transporter member 2 |
|---|---|
| Gene Symbol | SLC2A2 |
| Gene Full Name | solute carrier family 2 (facilitated glucose transporter), member 2 |
| Background | This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
| Function | Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. [UniProt] |
| Cellular Localization | Membrane; Multi-pass membrane protein. [UniProt] |
| Calculated MW | 57 kDa |
| PTM | N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG59122 anti-GLUT2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver cancer stained with ARG59122 anti-GLUT2 antibody.
