ARG45068
anti-GIV antibody [M012]
anti-GIV antibody [M012] for Western blot,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human
Overview
| Product Description | Mouse Monoclonal antibody [M012] recognizes GIV |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-P, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | M012 |
| Isotype | IgG1 |
| Target Name | GIV |
| Antigen Species | Human |
| Immunogen | Clone (M012) was generated from a recombinant protein that included amino acid residues within the C-terminal region of human Girdin. |
| Conjugation | Un-conjugated |
| Alternate Names | CCDC88A; Coiled-Coil Domain Containing 88A; KIAA1212; HkRP1; GRDN; APE; GIV; Girdin; G Alpha-Interacting Vesicle-Associated Protein; Akt-Phosphorylation Enhancer; Girders Of Actin Filaments; Hook-Related Protein 1; FLJ10392; Galpha-Interacting Vesicle-Associated Protein; Coiled-Coil Domain-Containing Protein 88A; Akt Phosphorylation Enhancer; Girders Of Actin Filament; PEHOL; PEHO |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G Purified. |
| Buffer | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| Stabilizer | 50% Glycerol and 0.1 % BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CCDC88A |
| Gene Full Name | Coiled-Coil Domain Containing 88A |
| Background | This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| Function | Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin. [Uniprot] |
| Cellular Localization | Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane. [Uniprot] |
| Calculated MW | 216 kDa |
| PTM | Phosphoprotein. [Uniprot] |
