ARG45070
anti-GIV Phospho (Ser1674) antibody
anti-GIV Phospho (Ser1674) antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GIV Phospho (Ser1674) |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GIV |
| Antigen Species | Human |
| Immunogen | Phospho-Girdin (Ser-1674) synthetic peptide (coupled to carrier) corresponding to amino acid residues around serine 1674 in human Girdin. This sequence has high homology to rat and mouse Girdin, and has low homology to similar regions in other Girdin family members. |
| Conjugation | Un-conjugated |
| Alternate Names | CCDC88A; Coiled-Coil Domain Containing 88A; KIAA1212; HkRP1; GRDN; APE; GIV; Girdin; G Alpha-Interacting Vesicle-Associated Protein; Akt-Phosphorylation Enhancer; Girders Of Actin Filaments; Hook-Related Protein 1; FLJ10392; Galpha-Interacting Vesicle-Associated Protein; Coiled-Coil Domain-Containing Protein 88A; Akt Phosphorylation Enhancer; Girders Of Actin Filament; PEHOL; PEHO |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified. |
| Buffer | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| Stabilizer | 50% Glycerol and 0.1 % BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CCDC88A |
| Gene Full Name | Coiled-Coil Domain Containing 88A |
| Background | This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| Function | Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin. [Uniprot] |
| Cellular Localization | Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane. [Uniprot] |
| Calculated MW | 216 kDa |
| PTM | Phosphoprotein. [Uniprot] |
