ARG41201
anti-GIT2 antibody
anti-GIT2 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GIT2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GIT2 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 450-510 of Human GIT2 (NP_476511.1). |
| Conjugation | Un-conjugated |
| Alternate Names | G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2; ARF GTPase-activating protein GIT2; CAT-2; Cool-interacting tyrosine-phosphorylated protein 2; CAT2; ARF GAP GIT2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | A431 |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q14161 Human ARF GTPase-activating protein GIT2 |
|---|---|
| Gene Symbol | GIT2 |
| Gene Full Name | G protein-coupled receptor kinase interacting ArfGAP 2 |
| Background | This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008] |
| Function | GTPase-activating protein for the ADP ribosylation factor family. [UniProt] |
| Calculated MW | 85 kDa |
Images (1) Click the Picture to Zoom In
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ARG41201 anti-GIT2 antibody WB image
Western blot: 25 µg of A431 cell lysate stained with ARG41201 anti-GIT2 antibody at 1:1000 dilution.
