ARG66400
anti-GIPR antibody
anti-GIPR antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GIPR |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GIPR |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 60-140 of Human GIPR. |
| Conjugation | Un-conjugated |
| Alternate Names | PGQTL2; GIP-R; Glucose-dependent insulinotropic polypeptide receptor; Gastric inhibitory polypeptide receptor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | ~ 53 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P48546 Human Gastric inhibitory polypeptide receptor |
|---|---|
| Gene Symbol | GIPR |
| Gene Full Name | gastric inhibitory polypeptide receptor |
| Background | This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011] |
| Function | This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. [UniProt] |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. [UniProt] |
| Calculated MW | 53 kDa |
| PTM | N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER. [UniProt] |
Images (3) Click the Picture to Zoom In
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ARG66400 anti-GIPR antibody IHC-P image
Immunohistochemistry: Human liver carcinom stained with ARG66400 anti-GIPR antibody.
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ARG66400 anti-GIPR antibody ICC/IF image
Immunofluorescence: MCF7 stained with ARG66400 anti-GIPR antibody.
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ARG66400 anti-GIPR antibody WB image
Western blot: A549 cell lysate stained with ARG66400 anti-GIPR antibody.
