ARG56689
anti-GDNF antibody
anti-GDNF antibody for ELISA,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GDNF |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | ELISA, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GDNF |
| Antigen Species | Human |
| Immunogen | E.coli derived Recombinant Human GDNF. (MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI) |
| Conjugation | Un-conjugated |
| Alternate Names | ATF; Astrocyte-derived trophic factor; HSCR3; hGDNF; Glial cell line-derived neurotrophic factor; HFB1-GDNF; ATF1; ATF2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.2) |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P39905 Human Glial cell line-derived neurotrophic factor Swiss-port # Q07731 Rat Glial cell line-derived neurotrophic factor |
|---|---|
| Gene Symbol | GDNF |
| Gene Full Name | glial cell derived neurotrophic factor |
| Background | This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010] |
| Function | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. [UniProt] |
| Calculated MW | 24 kDa |
Images (3) Click the Picture to Zoom In
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ARG56689 anti-GDNF antibody WB image
Western blot: 250 - 0.24 ng of Human GDNF stained with ARG56689 anti-GDNF antibody, under reducing conditions.
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ARG56689 anti-GDNF antibody WB image
Western blot: 250 - 0.24 ng of Human GDNF stained with ARG56689 anti-GDNF antibody, under non-reducing conditions.
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ARG56689 anti-GDNF antibody standard curve image
Sandwich ELISA: ARG56689 anti-GDNF antibody as a capture antibody at 0.5 - 2.0 µg/ml combined with ARG56798 anti-GDNF antibody (Biotin) as a detection antibody. Results of a typical standard run with optical density.
