ARG23602
anti-GDNF Receptor alpha 1 antibody
anti-GDNF Receptor alpha 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GDNF Receptor alpha 1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Specificity | GFR alpha 1 antibody is predicted to not cross-react with other members of the GFR alpha family of proteins. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GDNF Receptor alpha 1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around 14 aa (Center) of Human GDNF receptor alpha 1. |
| Conjugation | Un-conjugated |
| Alternate Names | GDNFR-alpha-1; GDNFRA; GFR-ALPHA-1; RET ligand 1; GFR-alpha-1; RET1L; GDNF receptor alpha-1; TRNR1; TGF-beta-related neurotrophic factor receptor 1; RETL1; GDNFR; GDNF family receptor alpha-1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Human Brain |
Properties
| Form | Liquid |
|---|---|
| Purification | DEAE purified. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GFRA1 |
| Gene Full Name | GDNF family receptor alpha 1 |
| Background | Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Feb 2009] |
| Function | Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity). [UniProt] |
| Calculated MW | 51 kDa |
Images (3) Click the Picture to Zoom In
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ARG23602 anti-GDNF Receptor alpha 1 antibody IHC-P image
Immunohistochemistry: Human brain tissue stained with ARG23602 anti-GDNF Receptor alpha 1 antibody at 1 µg/ml dilution.
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ARG23602 anti-GDNF Receptor alpha 1 antibody WB image
Western blot: Crude membrane fractions of Human brain, liver, kidney, and spleen lysates stained with ARG23602 anti-GDNF Receptor alpha 1 antibody at 1 µg/ml dilution.
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ARG23602 anti-GDNF Receptor alpha 1 antibody IHC-P image
Immunohistochemistry: Human brain tissue stained with ARG23602 anti-GDNF Receptor alpha 1 antibody at 2.5 µg/ml dilution.
