ARG58702
anti-GBP1 antibody
anti-GBP1 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GBP1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GBP1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 566-589 of Human GBP1 (QKESRIMKNEIQDLQTKMRRRKAC). |
| Conjugation | Un-conjugated |
| Alternate Names | Interferon-induced guanylate-binding protein 1; GTP-binding protein 1; HuGBP-1; GBP-1; Guanine nucleotide-binding protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Thimerosal and 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GBP1 |
| Gene Full Name | guanylate binding protein 1, interferon-inducible |
| Background | Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008] |
| Function | Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. [UniProt] |
| Cellular Localization | Cytoplasm. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Secreted. Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of interferon-gamma induction. Golgi membrane localization requires isoprenylation and the presence of another IFN-gamma-induced factor. [UniProt] |
| Calculated MW | 68 kDa |
| PTM | Isoprenylation is required for proper subcellular location. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG58702 anti-GBP1 antibody WB image
Western blot: 40 µg of U87, HeLa and MCF7 whole cell lysates stained with ARG58702 anti-GBP1 antibody at 0.5 µg/ml dilution.
