ARG44583
anti-GBA3 antibody
anti-GBA3 antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GBA3 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GBA3 |
| Antigen Species | Human |
| Immunogen | Human GBA3 recombinant protein (aa. sequence: Q17-L469). |
| Conjugation | Un-conjugated |
| Alternate Names | GBA3; Glucosylceramidase Beta 3 (Gene/Pseudogene); CBGL1; KLrP; Klotho-Related Protein; GLUC; Cytosolic Beta-Glucosidase-Like Protein 1; Glucosidase, Beta, Acid 3 (Cytosolic); Cytosolic Galactosylceramidase; Cytosolic Glucosylceramidase; Cytosolic Glycosylceramidase; Cytosolic Beta-Glucosidase; Glucosidase Beta Acid 3; Cytosolic GCase; EC 3.2.1.21; CBG; Glucosidase, Beta, Acid 3 (Gene/Pseudogene); Cytosolic Β-Glucosidase-Like Protein-1; Glucosylceramidase Beta 3; EC 3.2.1.46; EC 3.2.1.45 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Preservative | 4% Trehalose |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GBA3 |
| Gene Full Name | Glucosylceramidase Beta 3 (Gene/Pseudogene) |
| Background | The protein encoded by this gene is a cytosolic enzyme that can hydrolyze several types of glycosides. The enzyme has its highest activity at neutral pH and is predominantly expressed in human liver, kidney, intestine, and spleen. This gene is a polymorphic pseudogene, with the most common allele being the functional allele that encodes the full-length protein. Some individuals contain a single nucleotide polymorphism that results in a premature stop codon in the coding region, and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2022] |
| Function | Possesses transxylosylase activity in vitro using xylosylated ceramides/XylCers (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) as xylosyl donors and cholesterol as acceptor. Could also play a role in the catabolism of cytosolic sialyl free N-glycans. [Uniprot] |
| Cellular Localization | Cytoplasm. [Uniprot] |
| Calculated MW | 54 kDa |
Images (2) Click the Picture to Zoom In
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ARG44583 anti-GBA3 antibody WB image
Western blot: Rat kidney stained with ARG44583 anti-GBA3 antibody at 0.5 μg/mL dilution.
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ARG44583 anti-GBA3 antibody WB image
Western blot: Mouse kidney stained with ARG44583 anti-GBA3 antibody at 0.5 μg/mL dilution.
