Biochanin A inhibits cardiac hypertrophy and fibrosis in vivo and in vitro

WB / Mouse, Rat

Zhenyu Feng et al.
Biomed Pharmacother.,  (2024)

Shionone relieves oxygen-glucose deprivation/reoxygenation induced SH-SY5Y cells injury by inhibiting the p38 MAPK/NF-κB pathway

WB / Human

Xiaoli Zhou et al.
J Cardiothorac Surg,  (2024)

7,8-Dihydroxyflavone ameliorates cognitive impairment induced by repeated neonatal sevoflurane exposures in mice through increasing tau O-GlcNAcylation

WB / Mouse

Mingliang Xu et al.
Neurosci Lett.,  (2024)

The effect of long-term administration of green tea catechins on aging-related cardiac diastolic dysfunction and decline of troponin I

WB / Mouse

Junjun Quan et al.
pre-print,  (2024)

PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation

WB / Human, Mouse

Mingliang Xu et al.
Exp Neurol.,  (2024)

A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage

WB / Human

Yung-Ding Bow et al.
Cancer Cell Int.,  (2023)

SCP2 mediates the transport of lipid hydroperoxides to mitochondria in chondrocyte ferroptosis

WB / Rat

Tianming Dai et al.
Cell Death Discov.,  (2023)

Uric acid mitigates cognitive deficits via transcription factor EB - mediated microglial autophagy in mice models of Alzheimer's disease

WB / Mouse

Qian Xiao et al.
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Glucocorticoid-induced activation of NOX/ROS/NF-κB signaling in MSCs contributes to the development of GONFH

WB / Human

Huihui Xu et al.
Apoptosis.,  (2023)

Generation and characterization of two immortalized dermal fibroblast cell lines from the spiny mouse (Acomys)

WB / Acomys

Michele N Dill et al.
PLoS One.,  (2023)

黄芪甲苷预处理对大鼠肠缺血再灌注所致肺损伤的影响及其机制

WB / Rat

王蕾 et al.
中国中西医结合外科杂志,  (2023)

Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain

WB / Mouse

Chen-Yun Ding et al.
Cell Biosci.,  (2023)

Erucic acid improves the progress of pregnancy complicated with systemic lupus erythematosus by inhibiting the effector function of CD8+ T cells

WB / Human

Yanling Chang et al.
MedComm (2020).,  (2023)

PPAR- γ Activation Alleviates Osteoarthritis through Both the Nrf2/NLRP3 and PGC-1 α/ Δψ m Pathways by Inhibiting Pyroptosis

WB / Human

Zhencheng Feng et al.
PPAR Res,  (2023)

PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis

WB / Rat

Xiang Xue et al.
J Orthop Surg Res.,  (2023)

Discovery of the First Subnanomolar PPARα/δ Dual Agonist for the Treatment of Cholestatic Liver Diseases

WB / Mouse

Zhiqi Feng et al.
J Med Chem.,  (2023)

Resveratrol inhibits Toxoplasma gondii-induced lung injury, inflammatory cascade and evidences of its mechanism of action

WB / Mouse

Yu Nan Lu et al.
Phytomedicine.,  (2023)

Restraint stress promotes lung cancer xenograft growth via the IL2-Ras-Erk pathway

WB / Mouse

Ke Xu et al.
Research Square.,  (2023)

Knockdown of Porf-2 restores visual function after optic nerve crush injury

WB / Mouse

Di Chen et al.
Cell Death Dis.,  (2023)

Secreted Neutrophil Gelatinase-Associated Lipocalin Shows Stronger Ability to Inhibit Cyst Enlargement of ADPKD Cells Compared with Nonsecreted Form

WB / Mouse

Hsin-Yin Chuang et al.
Cells.,  (2022)

SCM-198 Alleviates Endometriosis by Suppressing Estrogen-ERα mediated Differentiation and Function of CD4+CD25+ Regulatory T Cells

WB / Mouse

Yun-Yun Li et al.
Int J Biol Sci,  (2022)

SCM-198 Prevents Endometriosis By Reversing Low Autophagy Levels Of Endometriotic Stromal Cells Via Inhibiting TNF-Α-Aromatase-Estrogen-Erα Pathway And Promoting PR Expression

WB / Human

Yikong Lin et al.
Research Square,  (2022)

Mesenchymal Stem Cells-Derived Exosomes Ameliorate Ischemia/Reperfusion Induced Acute Kidney Injury in a Porcine Model

WB / Pig

Jianni Huang et al.
Frontiers in Cell and Developmental Biology,  (2022)

Lack of interferon regulatory factor 3 leads to anxiety/depression-like behaviors through disrupting the balance of neuronal excitation and inhibition in mice

WB / Mouse

Junjie Li et al.
Genes & Diseases,  (2022)

Genetic labeling reveals cellular expression pattern of neuregulin 1 in mouse forebrain

WB / Mouse

Chen-Yun Ding et al.
Research square,  (2022)

Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis

WB / Mouse

QIAN Ming et al.
 Chinese Journal of Natural Medicines ,  (2022)

SCM-198 Prevents Endometriosis by Reversing Low Autophagy of Endometrial Stromal Cell via Balancing ERα and PR Signals

WB / Mouse

Yi-Kong Lin  et al.
Front Endocrinol (Lausanne),  (2022)

Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice

WB / Mouse

Binbin Cui  et al.
Front Pharmacol,  (2022)

Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury

WB / Human

Yuhua Zhou et al.
Cent Eur J Immunol .,  (2022)

The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis.

WB / Human

Huey-Jiun Ko et al.
Biomolecules.,  (2021)

Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid

WB / Human

Liu Liu et al.
Eur J Med Chem .,  (2021)

M351-0056 is a novel low MW compound modulating the actions of the immune-checkpoint protein VISTA.

WB / Human, Mouse

Xinlei Hu et al.
Br J Pharmacol.,  (2021)

Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation

WB / Rat

Lu Yang et al.
Korean J Physiol Pharmacol.,  (2021)

Evaluation of Class IIa Histone Deacetylases Expression and In Vivo Epigenetic Imaging in a Transgenic Mouse Model of Alzheimer's Disease

WB / Human

Yi-An Chen et al.
Int J Mol Sci.,  (2021)

Cardiac-Specific Gene TNNI3 as a Potential Oncogene for Kidney Cancer and Its Involvement in Wnt Signaling Pathway.

WB / Human

Weian Zhao et al.
Preprint.,  (2021)

7,8-dihydroxyflavone ameliorates motor deficits via regulating autophagy in MPTP-induced mouse model of Parkinson's disease

WB / Mouse

Li Zuo et al.
Cell Death Discov.,  (2021)

Excessive fibroblast growth factor 23 promotes renal fibrosis in mice with type 2 cardiorenal syndrome.

WB / Mouse, Rat

Huixin Hao et al.
Aging (Albany NY).,  (2021)

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer's Disease Pathology and Improve Cognitive Deficits.

WB / Human

Yi-An Chen et al.
Biomedicines.,  (2021)

Circ_0081572 inhibits the progression of periodontitis through regulating the miR-378h/RORA axis.

WB / Human

Jing Wang et al.
Arch Oral Biol.,  (2021)

SCM-198 ameliorates endometrial inflammation via suppressing the LPS-JNK-cJUN/cFOS-TLR4-NF-κB pathway

WB / Human

Yikong Lin et al.
Acta Biochim Biophys Sin. (Shanghai),  (2021)

Structural Basis of VSIG3: The Ligand for VISTA.

WB / Human

Xiaoxue Xie et al.
Front Immunol.,  (2021)

Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I.

WB / Human, Mouse

Geng Sun et al.
Eur J Med Chem.,  (2020)

SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury

WB / Human, Rat

Bingzheng Lu et al.
Oxid Med Cell Longev.,  (2020)

Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharide‑induced acute inflammatory apoM‑/‑ mice

WB / Mouse

Yuanping Shi et al.
Mol Med Rep.,  (2020)

ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17.

WB / Mouse

Chia-Wei Lin et al.
Neurosci Lett.,  (2020)

Cardiac troponin I R193H mutant interacts with HDAC1 to repress phosphodiesterase 4D expression in cardiomyocytes

WB / Mouse

Weian Zhao et al.
Genes Dis.,  (2020)

Study of isolation and characterization of extracellular vesicles in senescent tumor cells induced by chemotherapeutics.

WB / Human

Qi Zhou et al.
Chinese Journal of Immunology.,  (2020)

Epigenetic regulation of phosphodiesterase 4d in restrictive cardiomyopathy mice with cTnI mutations.

WB / Mouse

Zhao Weian et al.
Sci China Life Sci.,  (2019)

SCM-198 protects endometrial stromal cells from oxidative damage through Bax/Bcl-2 and ERK signaling pathways.

WB / Human

Yunyun Li et al.
Acta Biochim Biophys Sin.,  (2019)

Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells.

WB / Human

Li Sen et al.
J Exp Clin Cancer Res.,  (2019)

Genetic labeling reveals temporal and spatial expression pattern of D2 dopamine receptor in rat forebrain.

WB / Rat

Yu Qing et al.
Brain Struct Funct.,  (2019)

The effect of melatonin on cardio fibrosis in juvenile rats with pressure overload and deregulation of HDACs.

WB / Rat

Wu Yao et al.
Korean J Physiol Pharmacol.,  (2018)

Epigallocatechin-3 gallate prevents pressure overload-induced heart failure by up-regulating SERCA2a via histone acetylation modification in mice.

WB / Mouse

Liu Lifei et al.
PLoS One.,  (2018)

AdipoRon prevents l-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway.

WB / Rat

Hu Xinlei et al.
Acta Biochim Biophys Sin (Shanghai).,  (2018)

Hydrogen sulfide protects against endoplasmic reticulum stress and mitochondrial injury in nucleus pulposus cells and ameliorates intervertebral disc degeneration.

WB / Human

Xu D et al.
Pharmacol Res.,  (2017)

Cardiac Protection of Valsartan on Juvenile Rats with Heart Failure by Inhibiting Activity of CaMKII via Attenuating Phosphorylation

WB / Rat

Yao Wu et al.
BioMed Research International.,  (2017)

Checking transfer efficiency and equal loading via qualitative optical way in western blotting.

WB / Human

Gong JH et al.
Electrophoresis,  (2017)

Acute hyperglycemia suppresses left ventricular diastolic function and inhibits autophagic flux in mice under prohypertrophic stimulation.

WB / Mouse

Xie J et al.
Cardiovasc Diabetol.,  (2016)

Reciprocal regulation between O-GlcNAcylation and tribbles pseudokinase 2 (TRIB2) maintains transformative phenotypes in liver cancer cells.

WB / Human

Yao B et al.
Cell Signal.,  (2016)