PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation

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Mingliang Xu et al.
Exp Neurol.,  (2024)

Biochanin A inhibits cardiac hypertrophy and fibrosis in vivo and in vitro

WB / Mouse, Rat

Zhenyu Feng et al.
Biomed Pharmacother.,  (2024)

7,8-Dihydroxyflavone ameliorates cognitive impairment induced by repeated neonatal sevoflurane exposures in mice through increasing tau O-GlcNAcylation

WB / Mouse

Mingliang Xu et al.
Neurosci Lett.,  (2024)

The effect of long-term administration of green tea catechins on aging-related cardiac diastolic dysfunction and decline of troponin I

WB / Mouse

Junjun Quan et al.
pre-print,  (2024)

PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis

WB / Rat

Xiang Xue et al.
J Orthop Surg Res.,  (2023)

Discovery of the First Subnanomolar PPARα/δ Dual Agonist for the Treatment of Cholestatic Liver Diseases

WB / Mouse

Zhiqi Feng et al.
J Med Chem.,  (2023)

Resveratrol inhibits Toxoplasma gondii-induced lung injury, inflammatory cascade and evidences of its mechanism of action

WB / Mouse

Yu Nan Lu et al.
Phytomedicine.,  (2023)

Restraint stress promotes lung cancer xenograft growth via the IL2-Ras-Erk pathway

WB / Mouse

Ke Xu et al.
Research Square.,  (2023)

Knockdown of Porf-2 restores visual function after optic nerve crush injury

WB / Mouse

Di Chen et al.
Cell Death Dis.,  (2023)

A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage

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Yung-Ding Bow et al.
Cancer Cell Int.,  (2023)

SCP2 mediates the transport of lipid hydroperoxides to mitochondria in chondrocyte ferroptosis

WB / Rat

Tianming Dai et al.
Cell Death Discov.,  (2023)

Uric acid mitigates cognitive deficits via transcription factor EB - mediated microglial autophagy in mice models of Alzheimer's disease

WB / Mouse

Qian Xiao et al.
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Glucocorticoid-induced activation of NOX/ROS/NF-κB signaling in MSCs contributes to the development of GONFH

WB / Human

Huihui Xu et al.
Apoptosis.,  (2023)

Generation and characterization of two immortalized dermal fibroblast cell lines from the spiny mouse (Acomys)

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Michele N Dill et al.
PLoS One.,  (2023)

黄芪甲苷预处理对大鼠肠缺血再灌注所致肺损伤的影响及其机制

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王蕾 et al.
中国中西医结合外科杂志,  (2023)

Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain

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Chen-Yun Ding et al.
Cell Biosci.,  (2023)

Erucic acid improves the progress of pregnancy complicated with systemic lupus erythematosus by inhibiting the effector function of CD8+ T cells

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Yanling Chang et al.
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PPAR- γ Activation Alleviates Osteoarthritis through Both the Nrf2/NLRP3 and PGC-1 α/ Δψ m Pathways by Inhibiting Pyroptosis

WB / Human

Zhencheng Feng et al.
PPAR Res,  (2023)

Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis

WB / Mouse

QIAN Ming et al.
 Chinese Journal of Natural Medicines ,  (2022)

SCM-198 Prevents Endometriosis by Reversing Low Autophagy of Endometrial Stromal Cell via Balancing ERα and PR Signals

WB / Mouse

Yi-Kong Lin  et al.
Front Endocrinol (Lausanne),  (2022)

Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice

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Binbin Cui  et al.
Front Pharmacol,  (2022)

Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury

WB / Human

Yuhua Zhou et al.
Cent Eur J Immunol .,  (2022)

Secreted Neutrophil Gelatinase-Associated Lipocalin Shows Stronger Ability to Inhibit Cyst Enlargement of ADPKD Cells Compared with Nonsecreted Form

WB / Mouse

Hsin-Yin Chuang et al.
Cells.,  (2022)

SCM-198 Alleviates Endometriosis by Suppressing Estrogen-ERα mediated Differentiation and Function of CD4+CD25+ Regulatory T Cells

WB / Mouse

Yun-Yun Li et al.
Int J Biol Sci,  (2022)

SCM-198 Prevents Endometriosis By Reversing Low Autophagy Levels Of Endometriotic Stromal Cells Via Inhibiting TNF-Α-Aromatase-Estrogen-Erα Pathway And Promoting PR Expression

WB / Human

Yikong Lin et al.
Research Square,  (2022)

Mesenchymal Stem Cells-Derived Exosomes Ameliorate Ischemia/Reperfusion Induced Acute Kidney Injury in a Porcine Model

WB / Pig

Jianni Huang et al.
Frontiers in Cell and Developmental Biology,  (2022)

Lack of interferon regulatory factor 3 leads to anxiety/depression-like behaviors through disrupting the balance of neuronal excitation and inhibition in mice

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Junjie Li et al.
Genes & Diseases,  (2022)

Genetic labeling reveals cellular expression pattern of neuregulin 1 in mouse forebrain

WB / Mouse

Chen-Yun Ding et al.
Research square,  (2022)

Circ_0081572 inhibits the progression of periodontitis through regulating the miR-378h/RORA axis.

WB / Human

Jing Wang et al.
Arch Oral Biol.,  (2021)

SCM-198 ameliorates endometrial inflammation via suppressing the LPS-JNK-cJUN/cFOS-TLR4-NF-κB pathway

WB / Human

Yikong Lin et al.
Acta Biochim Biophys Sin. (Shanghai),  (2021)

Structural Basis of VSIG3: The Ligand for VISTA.

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Xiaoxue Xie et al.
Front Immunol.,  (2021)

The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis.

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Huey-Jiun Ko et al.
Biomolecules.,  (2021)

Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid

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Liu Liu et al.
Eur J Med Chem .,  (2021)

M351-0056 is a novel low MW compound modulating the actions of the immune-checkpoint protein VISTA.

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Xinlei Hu et al.
Br J Pharmacol.,  (2021)

Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation

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Lu Yang et al.
Korean J Physiol Pharmacol.,  (2021)

Evaluation of Class IIa Histone Deacetylases Expression and In Vivo Epigenetic Imaging in a Transgenic Mouse Model of Alzheimer's Disease

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Yi-An Chen et al.
Int J Mol Sci.,  (2021)

7,8-dihydroxyflavone ameliorates motor deficits via regulating autophagy in MPTP-induced mouse model of Parkinson's disease

WB / Mouse

Li Zuo et al.
Cell Death Discov.,  (2021)

Cardiac-Specific Gene TNNI3 as a Potential Oncogene for Kidney Cancer and Its Involvement in Wnt Signaling Pathway.

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Weian Zhao et al.
Preprint.,  (2021)

Excessive fibroblast growth factor 23 promotes renal fibrosis in mice with type 2 cardiorenal syndrome.

WB / Mouse, Rat

Huixin Hao et al.
Aging (Albany NY).,  (2021)

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer's Disease Pathology and Improve Cognitive Deficits.

WB / Human

Yi-An Chen et al.
Biomedicines.,  (2021)

ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17.

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Chia-Wei Lin et al.
Neurosci Lett.,  (2020)

Cardiac troponin I R193H mutant interacts with HDAC1 to repress phosphodiesterase 4D expression in cardiomyocytes

WB / Mouse

Weian Zhao et al.
Genes Dis.,  (2020)

Study of isolation and characterization of extracellular vesicles in senescent tumor cells induced by chemotherapeutics.

WB / Human

Qi Zhou et al.
Chinese Journal of Immunology.,  (2020)

Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I.

WB / Human, Mouse

Geng Sun et al.
Eur J Med Chem.,  (2020)

SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury

WB / Human, Rat

Bingzheng Lu et al.
Oxid Med Cell Longev.,  (2020)

Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharide‑induced acute inflammatory apoM‑/‑ mice

WB / Mouse

Yuanping Shi et al.
Mol Med Rep.,  (2020)

Epigenetic regulation of phosphodiesterase 4d in restrictive cardiomyopathy mice with cTnI mutations.

WB / Mouse

Zhao Weian et al.
Sci China Life Sci.,  (2019)

Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells.

WB / Human

Li Sen et al.
J Exp Clin Cancer Res.,  (2019)

Genetic labeling reveals temporal and spatial expression pattern of D2 dopamine receptor in rat forebrain.

WB / Rat

Yu Qing et al.
Brain Struct Funct.,  (2019)

SCM-198 protects endometrial stromal cells from oxidative damage through Bax/Bcl-2 and ERK signaling pathways.

WB / Human

Yunyun Li et al.
Acta Biochim Biophys Sin.,  (2019)

Epigallocatechin-3 gallate prevents pressure overload-induced heart failure by up-regulating SERCA2a via histone acetylation modification in mice.

WB / Mouse

Liu Lifei et al.
PLoS One.,  (2018)

AdipoRon prevents l-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway.

WB / Rat

Hu Xinlei et al.
Acta Biochim Biophys Sin (Shanghai).,  (2018)

The effect of melatonin on cardio fibrosis in juvenile rats with pressure overload and deregulation of HDACs.

WB / Rat

Wu Yao et al.
Korean J Physiol Pharmacol.,  (2018)

Hydrogen sulfide protects against endoplasmic reticulum stress and mitochondrial injury in nucleus pulposus cells and ameliorates intervertebral disc degeneration.

WB / Human

Xu D et al.
Pharmacol Res.,  (2017)

Cardiac Protection of Valsartan on Juvenile Rats with Heart Failure by Inhibiting Activity of CaMKII via Attenuating Phosphorylation

WB / Rat

Yao Wu et al.
BioMed Research International.,  (2017)

Checking transfer efficiency and equal loading via qualitative optical way in western blotting.

WB / Human

Gong JH et al.
Electrophoresis,  (2017)

Acute hyperglycemia suppresses left ventricular diastolic function and inhibits autophagic flux in mice under prohypertrophic stimulation.

WB / Mouse

Xie J et al.
Cardiovasc Diabetol.,  (2016)

Reciprocal regulation between O-GlcNAcylation and tribbles pseudokinase 2 (TRIB2) maintains transformative phenotypes in liver cancer cells.

WB / Human

Yao B et al.
Cell Signal.,  (2016)