ARG52306
anti-GABAB Receptor 1 phospho (Ser923) antibody
anti-GABAB Receptor 1 phospho (Ser923) antibody for Western blot and Rat
Neuroscience antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GABAB Receptor 1 phospho (Ser923) |
|---|---|
| Tested Reactivity | Rat |
| Predict Reactivity | Hu, Ms, Bov, NHuPrm |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GABAB Receptor 1 |
| Antigen Species | Rat |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser923 conjugated to KLH |
| Conjugation | Un-conjugated |
| Alternate Names | Gb1; GABA-B-R1; GABA-B receptor 1; GABA-BR1; GPRC3A; GABBR1-3; dJ271M21.1.2; dJ271M21.1.1; GABABR1; Gamma-aminobutyric acid type B receptor subunit 1; GB1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | Specific for ~102k GABAB R1 phosphorylated at Ser923. Immunolabeling of the GABAB R1 band is completely blocked by λ-phosphatase treatment. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| Stabilizer | 0.1 mg/ml BSA, 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9Z0U4 Rat Gamma-aminobutyric acid type B receptor subunit 1 |
|---|---|
| Gene Symbol | GABBR1 |
| Gene Full Name | gamma-aminobutyric acid (GABA) B receptor 1 |
| Background | Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABAB receptor effector coupling (Couve et al., 2004). Phosphorylation of Ser923 is thought to be important in the regulation of GABAB receptor function. |
| Research Area | Neuroscience antibody |
| Calculated MW | 108 kDa |
Images (1) Click the Picture to Zoom In
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ARG52306 anti-GABAB Receptor 1 phospho (Ser923) antibody WB image
Western blot: Rat synaptic membrane showing specific immunolabeling of the ~102 kDa GABAB R1 protein phosphorylated at Ser923 (control) stained with ARG52306 anti-GABAB Receptor 1 phospho (Ser923) antibody. The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: lambda-Ptase). The blot is identical to the control except that it was incubated in lambda-Ptase (1200 units for 30 min) before being exposed to the phospho-Ser923 GABAB antibody. The immunolabeling is completely eliminated by treatment with lambda-Ptase.
