ARG22236
anti-GABAA Receptor alpha 1 antibody [S95-35]
anti-GABAA Receptor alpha 1 antibody [S95-35] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [S95-35] recognizes GABAA Receptor alpha 1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Specificity | Detects ~55kDa. No cross-reactivity against GABA-A-R-Alpha 2 or -Alpha3. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S95-35 |
| Isotype | IgG2a |
| Target Name | GABAA Receptor alpha 1 |
| Antigen Species | Human |
| Immunogen | Fusion protein around aa. 355-394 of Human GABAA Receptor alpha 1 |
| Conjugation | Un-conjugated |
| Alternate Names | A; EJM; EIEE19; EJM5; Gamma-aminobutyric acid receptor subunit alpha-1; ECA4; GABA |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Gabra1 |
| Gene Full Name | gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 |
| Background | This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Function | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity). [UniProt] |
| Cellular Localization | Cell Junction, Cell membrane, postsynaptic cell membrane, Synapse |
| Calculated MW | 52 kDa |
Images (1) Click the Picture to Zoom In
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ARG22236 anti-GABAA Receptor alpha 1 antibody [S95-35] WB image
Western blot: Human cell line lysates stained with ARG22236 anti-GABAA Receptor alpha 1 antibody [S95-35] at 1:1000 dilution.
