ARG67025
anti-FOX3 / NeuN antibody [SQab30325]
anti-FOX3 / NeuN antibody [SQab30325] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Recombinant rabbit Monoclonal antibody [SQab30325] FOX3 / NeuN |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30325 |
| Isotype | IgG |
| Target Name | FOX3 / NeuN |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human NeuN |
| Conjugation | Un-conjugated |
| Protein Full Name | RNA binding protein fox-1 homolog 3 |
| Alternate Names | RBFOX3, RNA Binding Fox-1 Homolog 3, HRNBP3, FOX-3, Hexaribonucleotide Binding Protein 3, RNA Binding Protein, Fox-1 Homolog 3, RNA Binding Protein Fox-1 Homolog 3, Neuronal Nuclei Antigen, Fox-1 Homolog C, NeuN Antigen, NeuN, RNA Binding Protein, Fox-1 Homolog (C. Elegans) 3, Neuronal Nuclei, FOX3, NEUN |
Application Instructions
| Application Suggestion |
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| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Human brain tissue |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05%BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # A6NFN3 Human RNA binding protein fox-1 homolog 3 |
|---|---|
| Gene Symbol | RBFOX3 |
| Gene Full Name | RNA Binding Fox-1 Homolog 3 |
| Background | This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017] |
| Function | Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). [UniProt] |
| Cellular Localization | Cytoplasm, Nucleus |
| Calculated MW | 34 kDa |
| PTM | Methylation [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG67025 anti-NeuN antibody [SQab30325] IHC-P image.
Immunohistochemistry: Formalin-fixed and paraffin-embedded human brain tissue stained with ARG67025 anti-NeuN antibody [SQab30325].
Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer pH 9.0.
