ARG23582
anti-FOLR1 antibody [SF55 (BGN/1210/55)]
anti-FOLR1 antibody [SF55 (BGN/1210/55)] for ELISA and Bovine
Overview
| Product Description | Mouse Monoclonal antibody [SF55 (BGN/1210/55)] recognizes FOLR1. This product recognizes the folate receptor alpha, also known as folate binding protein (FBP) and Milk folate-binding protein. Folate receptor alpha is a 241 amino acid 30 kDa protein with a 19 amino acid signal peptide and a 7 amino acid c-terminal propeptide cleaved in the mature form. The folate receptor alpha has a high affinity for folate and several reduced folic acid derivatives and mediates the intracelullar delivery of 5 methyltetrahydrofolate. Membrane bound and soluble forms of a high affinity FBP have been found in kidney, placenta, serum, milk, and several cell lines.Mouse anti folate binding protein antibody, clone SF55 can enhance STAT3 activation through binding to the folatereceptor alpha (Hansen et al. 2015). |
|---|---|
| Tested Reactivity | Bov |
| Tested Application | ELISA |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SF55 (BGN/1210/55) |
| Isotype | IgG1 |
| Target Name | FOLR1 |
| Antigen Species | Bovine |
| Immunogen | Folate binding protein from Bovine milk. |
| Conjugation | Un-conjugated |
| Alternate Names | KB cells FBP; FBP; FOLR; Ovarian tumor-associated antigen MOv18; FR-alpha; Folate receptor alpha; Folate receptor 1; Adult folate-binding protein; Folate receptor, adult |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.1% Sodium azide. |
| Preservative | 0.1% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | FOLR1 |
|---|---|
| Gene Full Name | folate receptor 1 (adult) |
| Background | The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009] |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. [UniProt] |
| Calculated MW | 30 kDa |
| PTM | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. [UniProt] |
