ARG22263
anti-FKBP51 antibody [Hi51B]
anti-FKBP51 antibody [Hi51B] for ICC/IF,Western blot and Human,Mouse,Rat,Dog,Hamster,Rabbit
Overview
| Product Description | Mouse Monoclonal antibody [Hi51B] recognizes FKBP51 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Dog, Hm, Rb |
| Tested Application | ICC/IF, WB |
| Specificity | Detects ~51kDa. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | Hi51B |
| Isotype | IgG |
| Target Name | FKBP51 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide from Human FKBP51 |
| Conjugation | Un-conjugated |
| Alternate Names | HSP90-binding immunophilin; p54; FKBP-51; PPIase FKBP5; FK506-binding protein 5; Ptg-10; Rotamase; FKBP51; FKBP-5; FKBP54; 51 kDa FKBP; 51 kDa FK506-binding protein; EC 5.2.1.8; PPIase; Androgen-regulated protein 6; P54; AIG6; FF1 antigen; Peptidyl-prolyl cis-trans isomerase FKBP5; 54 kDa progesterone receptor-associated immunophilin |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS, 0.09% Sodium azide and 50% Glycerol |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q13451 Human Peptidyl-prolyl cis-trans isomerase FKBP5 Swiss-port # Q64378 Mouse Peptidyl-prolyl cis-trans isomerase FKBP5 |
|---|---|
| Gene Symbol | FKBP5 |
| Gene Full Name | FK506 binding protein 5 |
| Background | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. [UniProt] |
| Cellular Localization | Cytoplasm, Nucleus |
| Calculated MW | 51 kDa |
Images (2) Click the Picture to Zoom In
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ARG22263 anti-FKBP51 antibody [Hi51B] ICC/IF image
Immunocytochemistry: Mouse MK cells stained with ARG22263 anti-FKBP51 antibody [Hi51B] (red).
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ARG22263 anti-FKBP51 antibody [Hi51B] WB image
Western blot: Human HeLa cell lysates stained with ARG22263 anti-FKBP51 antibody [Hi51B] at 1:1000 dilution.
