ARG57541
anti-FHL2 antibody [21D11]
anti-FHL2 antibody [21D11] for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [21D11] recognizes FHL2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 21D11 |
| Isotype | IgG1, kappa |
| Target Name | FHL2 |
| Antigen Species | Human |
| Immunogen | Recombinant Human FHL2 (aa. 1-279) purified from E. coli. |
| Conjugation | Un-conjugated |
| Alternate Names | AAG11; Four and a half LIM domains protein 2; SLIM-3; FHL-2; LIM domain protein DRAL; DRAL; SLIM3; Skeletal muscle LIM-protein 3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 10% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q14192 Human Four and a half LIM domains protein 2 |
|---|---|
| Gene Symbol | FHL2 |
| Gene Full Name | four and a half LIM domains 2 |
| Background | This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011] |
| Function | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. [UniProt] |
| Calculated MW | 32 kDa |
Images (1) Click the Picture to Zoom In
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ARG57541 anti-FHL2 antibody [21D11] WB image
Western blot: 40 µg of HeLa, A549, MCF7, SK-OV-3 and HT1080 cell lysates stained with ARG57541 anti-FHL2 antibody [21D11] at 1:1000 dilution.
