ARG67058
anti-FCGRT antibody [SQab30340]
anti-FCGRT antibody [SQab30340] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Recombinant Rabbit Monoclonal antibody [SQab30340] recognizes FCGRT |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30340 |
| Isotype | IgG |
| Target Name | FCGRT |
| Antigen Species | Human |
| Immunogen | Recombinant protein fragment of FCGRT |
| Conjugation | Un-conjugated |
| Protein Full Name | IgG receptor FcRn large subunit p51 |
| Alternate Names | FCGRT; Fc Gamma Receptor And Transporter ; Neonatal Fc Receptor; FcgammaRn; FcRn; Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor; Transmembrane Alpha Chain Of The Neonatal Receptor; Fc Fragment Of IgG, Receptor, Transporter, Alpha; IgG Fc Fragment Receptor Transporter Alpha Chain; Fc Fragment Of IgG Receptor And Transporter; IgG Receptor FcRn Large Subunit P51; FCRN; Major Histocompatibility Complex Class I-Like Fc Receptor; Immunoglobulin Receptor, Intestinal, Heavy Chain; Neonatal Fc-Receptor For Ig; FCRN Alpha-Chain; FcRn Alpha Chai; Alpha-Chain |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | -20°C |
| Note | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links |
Swiss-port # P55899 Human IgG receptor FcRn large subunit p51 |
|---|---|
| Gene Symbol | FCGRT |
| Gene Full Name | Fc Gamma Receptor And Transporter |
| Background | This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] |
| Function | IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. |
| Cellular Localization | Cell membrane, Endosome, Membrane. [UniProt] |
| PTM | Disulfide bond, Glycoprotein, Phosphoprotein. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG67058 anti-FCGRT antibody [SQab30340] IHC-P image
Immunohistochemistry: Human tonsil tissue stained with ARG67058 anti-FCGRT antibody [SQab30340] at 1:100 dilution.
