ARG41915
anti-FBXO45 antibody
anti-FBXO45 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes FBXO45 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | FBXO45 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide between aa. 83-115 of Human FBXO45. |
| Conjugation | Un-conjugated |
| Alternate Names | F-box/SPRY domain-containing protein 1; F-box only protein 45; Fbx45; hFbxo45 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | HT-1080 | ||||
| Observed Size | ~ 30 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide. |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P0C2W1 Human F-box/SPRY domain-containing protein 1 |
|---|---|
| Gene Symbol | FBXO45 |
| Gene Full Name | F-box protein 45 |
| Background | Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011] |
| Function | Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. [UniProt] |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. [UniProt] |
| Calculated MW | 31 kDa |
Images (1) Click the Picture to Zoom In
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ARG41915 anti-FBXO45 antibody WB image
Western blot: 20 µg of HT-1080 whole cell lysate stained with ARG41915 anti-FBXO45 antibody at 1:2000 dilution.
