ARG58607
anti-FANCC antibody
anti-FANCC antibody for ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes FANCC |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | FANCC |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide between aa. 527-555 of Human FANCC. |
| Conjugation | Un-conjugated |
| Alternate Names | FA3; FACC; Protein FACC; Fanconi anemia group C protein; FAC |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | HepG2 |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | FANCC |
| Gene Full Name | Fanconi anemia, complementation group C |
| Background | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008] |
| Function | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. [UniProt] |
| Cellular Localization | Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic. [UniProt] |
| Calculated MW | 63 kDa |
Images (2) Click the Picture to Zoom In
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ARG58607 anti-FANCC antibody ICC/IF image
Immunofluorescence: U251 cells stained with ARG58607 anti-FANCC antibody (green) at 1:25 dilution. DAPI (blue) for nuclear staining.
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ARG58607 anti-FANCC antibody WB image
Western blot: 35 µg of HepG2 cell lysate stained with ARG58607 anti-FANCC antibody at 1:1000 dilution.
