ARG45348
anti-Endostatin antibody [3H11]
anti-Endostatin antibody [3H11] for IHC-Formalin-fixed paraffin-embedded sections and Mouse
Overview
| Product Description | Rat Monoclonal antibody [3H11] recognizes Endostatin |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | IHC-P |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 3H11 |
| Isotype | IgG2 |
| Target Name | Endostatin |
| Antigen Species | Mouse |
| Immunogen | Recombinant Mouse Endostatin. |
| Conjugation | Un-conjugated |
| Alternate Names | KS; KNO; KNO1; Collagen alpha-1(XVIII) chain |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Powder |
|---|---|
| Purification | Protein G/A chromatography |
| Buffer | PBS |
| Reconstitution | PBS |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | COL18A1 |
| Gene Full Name | collagen, type XVIII, alpha 1 |
| Background | This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| Function | Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. [UniProt] |
| Cellular Localization | Basement membrane; Extracellular matrix; Secreted. [UniProt] |
| Highlight | Related products: Endostatin antibodies; Endostatin ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| Calculated MW | 182 kDa |
| PTM | Disulfide bond; Glycoprotein; Hydroxylation; Phosphoprotein; Proteoglycan. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG45348 anti-Endostatin antibody [3H11] IHC-P image
Immunohistochemistry: Mouse lung stained with ARG45348 anti-Endostatin antibody [3H11].
