ARG44826
anti-EXOSC10 / Rrp6p antibody
anti-EXOSC10 / Rrp6p antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes EXOSC10 / Rrp6p |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | EXOSC10 / Rrp6p |
| Antigen Species | Human |
| Epitope | PFRMFLPSLG HRAPVSQAAK FDPSTKIYEI SNRWKLAQVQ VQKDSKEAVK KKAAEQTAAR EQAKEACKAA AEQAISVRQQ VVLENAAKKR ERATSDPRTT EQKQEKKRLK ISKKPKDPEP PEKEFTPYDY SQSDFKAFAG NSKSKVSSQF DPNKQTPSGK |
| Conjugation | Un-conjugated |
| Alternate Names | EXOSC10; Exosome Component 10; PM/Scl-100; RRP6; PM-Scl; PMSCL2; Rrp6p; P2; P3; P4; P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen; Polymyositis/Scleroderma Autoantigen 100 KDa; Polymyositis/Scleroderma Autoantigen 2; Exosome Complex Component 10; PMSCL; Polymyositis/Scleroderma Autoantigen 2 (100kD); Polymyositis/Scleroderma Autoantigen 2, 100kDa; Autoantigen PM/Scl 2; Autoantigen PM-SCL; EC 3.1.13.- |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | EXOSC10 |
|---|---|
| Gene Full Name | Exosome Component 10 |
| Background | Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA catabolic process; maturation of 5.8S rRNA; and negative regulation of telomere maintenance via telomerase. Located in cytosol; nuclear lumen; and transcriptionally active chromatin. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022] |
| Function | Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins. [UniProt] |
| Cellular Localization | Cytoplasm, Exosome, Nucleus. [UniProt] |
| PTM | Isopeptide bond, Phosphoprotein, Ubl conjugation. [UniProt] |
Images (3) Click the Picture to Zoom In
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ARG44826 anti-EXOSC10/Rrp6p antibody IHC-P image
Immunohistochemistry: Human skin stained with ARG44826 anti-EXOSC10/Rrp6p antibody at 5 µg/mL dilution.
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ARG44826 anti-EXOSC10/Rrp6p antibody WB image
Western blot: HEK293 stained with ARG44826 anti-EXOSC10/Rrp6p antibody at 1 µg/mL dilution.
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ARG44826 anti-EXOSC10/Rrp6p antibody IP image
Immunoprecipitation: HEK293 lysate immunoprecipitated with 2.5 µg of ARG44826 anti-EXOSC10/Rrp6p antibody.
