ARG42880
anti-EXOC3 / rSec6 antibody
anti-EXOC3 / rSec6 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes EXOC3 / rSec6 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | EXOC3 / rSec6 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human EXOC3 / rSec6. |
| Conjugation | Un-conjugated |
| Alternate Names | SEC6L1; Exocyst complex component Sec6; Sec6p; Exocyst complex component 3; SEC6 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Positive Control | NIH/3T3 | ||||||||||
| Observed Size | ~ 85 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Concentration | Batch dependent |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | EXOC3 |
| Gene Full Name | exocyst complex component 3 |
| Background | The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008] |
| Function | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. [UniProt] |
| Cellular Localization | Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Midbody. Golgi apparatus. Note=Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). During mitosis, early recruitment to the midbody requires RALA, but not RALB, and EXOC2. In late stages of cytokinesis, localization to the midbody is RALB-dependent (PubMed:18756269). [UniProt] |
| Calculated MW | 86 kDa |
Images (1) Click the Picture to Zoom In
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ARG42880 anti-EXOC3 / rSec6 antibody WB image
Western blot: NIH/3T3 cell lysate stained with ARG42880 anti-EXOC3 / rSec6 antibody at 1:1000 dilution.
