ARG55577
anti-EREG antibody
anti-EREG antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cancer antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes EREG |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | EREG |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 137-165 (C-terminus) of Human EREG. |
| Conjugation | Un-conjugated |
| Alternate Names | Proepiregulin; EPR; Ep; ER |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | HepG2 |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | EREG |
| Gene Full Name | epiregulin |
| Background | This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015] |
| Function | Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. [UniProt] |
| Cellular Localization | Epiregulin: Secreted, extracellular space. |
| Research Area | Cancer antibody; Signaling Transduction antibody |
| Calculated MW | 19 kDa |
Images (3) Click the Picture to Zoom In
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ARG55577 anti-EREG antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded colon carcinoma stained with ARG55577 anti-EREG antibody.
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ARG55577 anti-EREG antibody WB image
Western blot: 20 µg of HepG2 cell lysate stained with ARG55577 anti-EREG antibody at 1:1000 dilution.
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ARG55577 anti-EREG antibody FACS image
Flow Cytometry: HepG2 cells stained with ARG55577 anti-EREG antibody (right histogram) or without primary antibody as control (left histogram), followed by incubation with FITC labelled secondary antibody.
