ARG59188
anti-EOMES / TBR2 antibody
anti-EOMES / TBR2 antibody for Western blot and Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes EOMES / TBR2 |
|---|---|
| Tested Reactivity | Ms, Rat |
| Predict Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | EOMES / TBR2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to T310-D532 of Human EOMES / TBR2. |
| Conjugation | Un-conjugated |
| Alternate Names | TBR-2; T-box brain protein 2; Eomesodermin homolog; TBR2; T-brain-2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | EOMES |
| Gene Full Name | eomesodermin |
| Background | This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
| Function | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 73 kDa |
Images (1) Click the Picture to Zoom In
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ARG59188 anti-EOMES / TBR2 antibody WB image
Western blot: 50 µg of samples under reducing conditions. Rat spleen, Rat thymus, Mouse spleen and Mouse thymus lysates stained with ARG59188 anti-EOMES / TBR2 antibody at 0.5 µg/ml, overnight at 4°C.
