ARG42013
anti-ELP3 / KAT9 antibody
anti-ELP3 / KAT9 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ELP3 / KAT9 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ELP3 / KAT9 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 358-547 of Human ELP3 / KAT9 (NP_060561.3). |
| Conjugation | Un-conjugated |
| Alternate Names | KAT9; Elongator complex protein 3; hELP3; EC 2.3.1.48 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Mouse kidney | ||||||
| Observed Size | ~ 62 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ELP3 |
| Gene Full Name | elongator acetyltransferase complex subunit 3 |
| Background | ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009] |
| Function | Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin. May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). [UniProt] |
| Cellular Localization | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Cytoplasm. Nucleus. [UniProt] |
| Calculated MW | 62 kDa |
Images (2) Click the Picture to Zoom In
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ARG42013 anti-ELP3 / KAT9 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse cerebellum tissue stained with ARG42013 anti-ELP3 / KAT9 antibody at 1:100 dilution.
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ARG42013 anti-ELP3 / KAT9 antibody WB image
Western blot: 25 µg of Mouse kidney lysate stained with ARG42013 anti-ELP3 / KAT9 antibody at 1:1000 dilution.
