ARG42013

anti-ELP3 / KAT9 antibody

anti-ELP3 / KAT9 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes ELP3 / KAT9
Tested Reactivity Hu, Ms, Rat
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name ELP3 / KAT9
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 358-547 of Human ELP3 / KAT9 (NP_060561.3).
Conjugation Un-conjugated
Alternate Names KAT9; Elongator complex protein 3; hELP3; EC 2.3.1.48

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse kidney
Observed Size ~ 62 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 55140 Human ELP3

GeneID: 74195 Mouse ELP3

Swiss-port # Q9CZX0 Mouse Elongator complex protein 3

Swiss-port # Q9H9T3 Human Elongator complex protein 3

Gene Symbol ELP3
Gene Full Name elongator acetyltransferase complex subunit 3
Background ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009]
Function Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin. May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). [UniProt]
Cellular Localization Cytoplasm. Isoform 1: Nucleus. Isoform 2: Cytoplasm. Nucleus. [UniProt]
Calculated MW 62 kDa

Images (2) Click the Picture to Zoom In

  • ARG42013 anti-ELP3 / KAT9 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Mouse cerebellum tissue stained with ARG42013 anti-ELP3 / KAT9 antibody at 1:100 dilution.

  • ARG42013 anti-ELP3 / KAT9 antibody WB image

    Western blot: 25 µg of Mouse kidney lysate stained with ARG42013 anti-ELP3 / KAT9 antibody at 1:1000 dilution.