ARG22756
anti-EBV LMP2A antibody [15F9]
anti-EBV LMP2A antibody [15F9] for IHC-Formalin-fixed paraffin-embedded sections,Western blot and EBV
Overview
| Product Description | Rat Monoclonal antibody [15F9] recognizes EBV LMP2A This antibody recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV). EBV is a Human herpesvirus, which is associated with conditions such as Hodgkinas disease and Burkittas Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals. This antibody specifically recognizes LMP2A and does not cross react with LMP2B. |
|---|---|
| Tested Reactivity | EBV |
| Tested Application | IHC-P, WB |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 15F9 |
| Isotype | IgG1 |
| Target Name | EBV LMP2A |
| Antigen Species | Virus |
| Immunogen | Bacterial TrpE-LMP2A fusion protein |
| Conjugation | Un-conjugated |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Boil tissue section in Sodium citrate buffer (pH 6.0) * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% Sodium azide. |
| Preservative | 0.09% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
