ARG63183
anti-Dysadherin antibody
anti-Dysadherin antibody for Western blot and Human
Controls and Markers antibody; Signaling Transduction antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes Dysadherin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Specificity | NP_054883.3, NP_659003.1and NP_001158077.1 are variants that represent the same protein. |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Dysadherin |
| Antigen Species | Human |
| Immunogen | GKCRQLSRLCRNHCR |
| Conjugation | Un-conjugated |
| Alternate Names | HSPC113; KCT1; IWU1; Dysadherin; FXYD domain-containing ion transport regulator 5; DYSAD; PRO6241; RIC; OIT2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q96DB9 Human FXYD domain-containing ion transport regulator 5 |
|---|---|
| Background | This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009] |
| Research Area | Controls and Markers antibody; Signaling Transduction antibody |
| Calculated MW | 19 kDa |
| PTM | Glycosylated. |
Images (1) Click the Picture to Zoom In
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ARG63183 anti-Dysadherin antibody WB image
Western Blot: Human Spleen lysate (RIPA buffer, 30µg total protein per lane) stained with ARG63183 anti-Dysadherin antibody at 0.5 µg/ml dilution.
