ARG54239
anti-Drebrin antibody [DBN-N-03] (PE)
anti-Drebrin antibody [DBN-N-03] (PE) for Flow cytometry and Human
Cancer antibody; Neuroscience antibody; Signaling Transduction antibody
Overview
| Product Description | PE-conjugated Mouse Monoclonal antibody [DBN-N-03] recognizes Drebrin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Specificity | The clone DBN-N-03 recognizes drebrin, an approximately 100-125 kDa regulator of actin cytoskeleton. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | DBN-N-03 |
| Isotype | IgG2b |
| Target Name | Drebrin |
| Antigen Species | Human |
| Immunogen | Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326) |
| Conjugation | PE |
| Alternate Names | Developmentally-regulated brain protein; D0S117E; Drebrin |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| Buffer | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| Preservative | 15 mM Sodium azide |
| Stabilizer | 0.2% (w/v) high-grade protease free BSA |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DBN1 |
| Gene Full Name | drebrin 1 |
| Background | Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse. |
| Function | Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. [UniProt] |
| Research Area | Cancer antibody; Neuroscience antibody; Signaling Transduction antibody |
| Calculated MW | 71 kDa |
