ARG45122
anti-Dhh antibody [6A12]
anti-Dhh antibody [6A12] for IHC-Formalin-fixed paraffin-embedded sections and Mouse
Overview
| Product Description | Rat Monoclonal antibody recognizes Dhh |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | IHC-P |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 6A12 |
| Isotype | IgG2 |
| Target Name | Dhh |
| Antigen Species | Mouse |
| Immunogen | Mouse recombinant dhh N-terminal fragment. |
| Conjugation | Un-conjugated |
| Alternate Names | DHH; Desert Hedgehog Signaling Molecule; HHG-3; Desert Hedgehog Protein; MGC35145; Desert Hedgehog (Drosophila) Homolog; Desert Hedgehog; EC 3.1.-.-; GDXYM; SRXY7; GDMN |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G/A chromatography |
| Buffer | PBS |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DHH |
| Gene Full Name | Desert Hedgehog Signaling Molecule |
| Background | This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010] |
| Function | In Schwann cells, controls the development of the peripheral nerve sheath and the transition of mesenchymal cells to form the epithelium-like structure of the perineurial tube. [Uniprot] |
| Cellular Localization | Cell membrane; Endoplasmic reticulum; Golgi apparatus; Membrane; Secreted. [Uniprot] |
| Calculated MW | 44 kDa |
Images (1) Click the Picture to Zoom In
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ARG45122 anti-Dhh antibody [6A12] IHC-P image
Immunohistochemistry: Mouse Kidney stained with ARG45122 anti-Dhh antibody [6A12] at 1:400 dilution.
