ARG70009
anti-Desmocollin 1 antibody
anti-Desmocollin 1 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Desmocollin 1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Desmocollin 1 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide within 659 to 687 aa (C-terminus) of Human Desmocollin 1 protein (NP_004939.1) |
| Conjugation | Un-conjugated |
| Alternate Names | DG2/DG3; Desmocollin-1; CDHF1; Desmosomal glycoprotein 2/3; Cadherin family member 1 |
Application Instructions
| Application Suggestion |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | A375 |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DSC1 |
| Gene Full Name | desmocollin 1 |
| Background | DSC1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. [Uniprot] |
| Research Area | Signaling Transduction antibody |
| Calculated MW | 100 kDa |
Images (2) Click the Picture to Zoom In
-
ARG70009 anti-Desmocollin 1 antibody WB image
Western blot: 35 µg of A375 cell lysate stained with ARG70009 anti-Desmocollin 1 antibody.
-
ARG70009 anti-Desmocollin 1 antibody FACS image
Flow Cytometry: A375 cells stained with ARG70009 anti-Desmocollin 1 antibody (right histogram) or without primary antibody control (left histogram).
