ARG54352
anti-DcR3 antibody
anti-DcR3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DcR3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Specificity | This antibody recognizes human, mouse, and rat DcR3 (33kDa). |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DcR3 |
| Antigen Species | Human |
| Immunogen | Peptide corresponding to aa 31-46 of human DcR3 precursor (accession no. |
| Conjugation | Un-conjugated |
| Alternate Names | M68E; Tumor necrosis factor receptor superfamily member 6B; M68; DCR3; Decoy receptor 3; DJ583P15.1.1; Decoy receptor for Fas ligand; DcR3; TR6 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Human heart, brain and kidney |
Properties
| Form | Liquid |
|---|---|
| Purification | Immunoaffinity chroma-tography |
| Buffer | PBS (pH 7.4) and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O95407 Human Tumor necrosis factor receptor superfamily member 6B |
|---|---|
| Gene Symbol | TNFRSF6B |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 6b, decoy |
| Background | Several novel members in the TNF receptor family, including DR3, DR4, DR5 and DR6, function as cell death receptors. Two decoy receptors, DcR1 and DcR2, compete with DR4 and DR5 for binding of their ligand, TRAIL. Another decoy receptor, DcR3/TR6 was discovered recently. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane-associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL- and LIGHT-induced apoptosis. DcR3 transcript is expressed in some lung and colon carcinomas and in some normal tissues. |
| Function | Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. [UniProt] |
| Research Area | Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody |
| Calculated MW | 33 kDa |
Images (2) Click the Picture to Zoom In
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ARG54352 anti-DcR3 antibody WB image
Western Blot: H: human heart; B: brain; K: kidney stained with ARG54352 anti-DcR3 antibody.
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ARG54352 anti-DcR3 antibody IHC-P image
Immunohistochemistry: human heart tissue stained with ARG54352 anti-DcR3 antibody at 1 μg/ml dilution.
