ARG57530
anti-DUSP6 antibody
anti-DUSP6 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DUSP6 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, IP, WB |
| Specificity | This antibody detects endogenous levels of total DUSP6. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DUSP6 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human DUSP6. |
| Conjugation | Un-conjugated |
| Alternate Names | Dual specificity protein phosphatase PYST1; MKP-3; MAP kinase phosphatase 3; MKP3; EC 3.1.3.16; PYST1; Dual specificity protein phosphatase 6; Mitogen-activated protein kinase phosphatase 3; EC 3.1.3.48; HH19 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||||
| Positive Control | NIH/3T3 | ||||||||||||
| Observed Size | ~ 38 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified by affinity chromatography. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DUSP6 |
| Gene Full Name | dual specificity phosphatase 6 |
| Background | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014] |
| Function | Inactivates MAP kinases. Has a specificity for the ERK family. [UniProt] |
| Cellular Localization | Nucleus |
| Calculated MW | 42 kDa |
Images (2) Click the Picture to Zoom In
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ARG57530 anti-DUSP6 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human thyroid stained with ARG57530 anti-DUSP6 antibody.
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ARG57530 anti-DUSP6 antibody WB image
Western blot: NIH/3T3 cell lysate stained with ARG57530 anti-DUSP6 antibody.
