ARG41176
anti-DHRS9 antibody
anti-DHRS9 antibody for ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DHRS9 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DHRS9 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 18-319 of Human DHRS9 (NP_001135743.1). |
| Conjugation | Un-conjugated |
| Alternate Names | Tracheobronchial epithelial cell-specific retinol dehydrogenase; 3-alpha-HSD; Short-chain dehydrogenase/reductase retSDR8; RDH-TBE; NADP-dependent retinol dehydrogenase/reductase; 3-alpha hydroxysteroid dehydrogenase; Dehydrogenase/reductase SDR family member 9; RDH15; RDHL; RDH-E2; RETSDR8; Short chain dehydrogenase/reductase family 9C member 4; Retinol dehydrogenase 15; RDHTBE; EC 1.1.-.-; SDR9C4; 3ALPHA-HSD |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | THP-1 | ||||||
| Observed Size | 33 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DHRS9 |
| Gene Full Name | dehydrogenase/reductase (SDR family) member 9 |
| Background | This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| Function | 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. [UniProt] |
| Cellular Localization | Microsome membrane. Endoplasmic reticulum membrane. Note=Associated with microsomal membranes. [UniProt] |
| Calculated MW | 35 kDa |
Images (2) Click the Picture to Zoom In
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ARG41176 anti-DHRS9 antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG41176 anti-DHRS9 antibody.
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ARG41176 anti-DHRS9 antibody WB image
Western blot: 25 µg of THP-1 cell lysate stained with ARG41176 anti-DHRS9 antibody at 1:1000 dilution.
