ARG57940
anti-DAO / D Amino Acid Oxidase antibody
anti-DAO / D Amino Acid Oxidase antibody for ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DAO / D Amino Acid Oxidase |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DAO / D Amino Acid Oxidase |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-347 of Human DAO (NP_001908.3). |
| Conjugation | Un-conjugated |
| Alternate Names | EC 1.4.3.3; D-amino-acid oxidase; DAO; DAMOX; OXDA; DAAO |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Raji | ||||||
| Observed Size | 36 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DAO |
| Gene Full Name | D-amino-acid oxidase |
| Background | This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008] |
| Function | Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. [UniProt] |
| Cellular Localization | Peroxisome. [UniProt] |
| Calculated MW | 39 kDa |
Images (2) Click the Picture to Zoom In
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ARG57940 anti-DAO / D Amino Acid Oxidase antibody ICC/IF image
Immunofluorescence: MCF-7 cells stained with ARG57940 anti-DAO / D Amino Acid Oxidase antibody.
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ARG57940 anti-DAO / D Amino Acid Oxidase antibody WB image
Western blot: 25 µg of Raji cell lysate stained with ARG57940 anti-DAO / D Amino Acid Oxidase antibody at 1:1000 dilution.
