ARG42331
anti-Cytokeratins antibody [C-11] (Biotin)
anti-Cytokeratins antibody [C-11] (Biotin) for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Mammal
Overview
| Product Description | Biotin-conjugated Mouse Monoclonal antibody [C-11] recognizes Cytokeratins |
|---|---|
| Tested Reactivity | Mamm |
| Tested Application | FACS, ICC/IF, IHC-P, IP, WB |
| Specificity | The antibody C-11 reacts with Cytokeratin peptides 4, 5, 6, 8, 10, 13, 18. Cytokeratins are members of intermediate filaments subfamily intracellular proteins represented in epithelial tissues. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | C-11 |
| Isotype | IgG1 |
| Target Name | Cytokeratins |
| Antigen Species | Human |
| Immunogen | Keratin-enriched preparation from Human epidermoid carcinoma cell line A431. |
| Conjugation | Biotin |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | KRT4; KRT5; KRT6; KRT8; KRT10; KRT13; KRT18 |
|---|---|
| Gene Full Name | keratin 4, type I; keratin 5, type I; keratin 6, type I; keratin 8, type I; keratin 10, type I; keratin 13, type I; keratin 18, type I |
| Background | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
| Calculated MW | 57 kDa |
