ARG44853
anti-Cytokeratin 3 / CK3 antibody
anti-Cytokeratin 3 / CK3 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes Cytokeratin 3 / CK3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | Cytokeratin 3 / CK3 |
| Antigen Species | Human |
| Conjugation | Un-conjugated |
| Alternate Names | KRT3; Keratin 3; K3; Keratin, Type II Cytoskeletal 3; CK3; Type-II Keratin Kb3; 65 KDa Cytokeratin; Cytokeratin 3; CK-3; Keratin 3, Type II; Cytokeratin-3; Keratin-3; MECD2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KRT3 |
| Gene Full Name | Keratin 3 |
| Background | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
| Function | There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). [Uniprot] |
| Cellular Localization | Intermediate filament, Keratin. [Uniprot] |
| PTM | Methylation, Phosphoprotein. [Uniprot] |
Images (1) Click the Picture to Zoom In
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ARG44853 anti-Cytokeratin 3 / CK3 antibody IHC-P image
Immunohistochemistry: skin stained with ARG44853 anti-Cytokeratin 3 / CK3 antibody at 7.5 µg/mL dilution.
