ARG43846
anti-Cyclin D1 antibody [DCS-6] (Biotin)
anti-Cyclin D1 antibody [DCS-6] (Biotin) for Flow cytometry,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
Overview
| Product Description | Biotin-conjugated Mouse Monoclonal antibody recognizes Cyclin D1. |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat, NHuPrm |
| Tested Application | FACS, IHC-Fr, IHC-P, IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | DCS-6 |
| Isotype | IgG2a |
| Target Name | Cyclin D1 |
| Antigen Species | Human |
| Immunogen | Human Cyclin D1 recombinant protein. |
| Conjugation | Biotin |
| Protein Full Name | G1/S-specific cyclin-D1 |
| Alternate Names | CCND1; Cyclin D1; U21B31; PRAD1; BCL1; B-Cell Lymphoma 1 Protein; G1/S-Specific Cyclin-D1; B-Cell CLL/Lymphoma 1; BCL-1 Oncogene; PRAD1 Oncogene; D11S287E; Cyclin D1 (PRAD1: Parathyroid Adenomatosis 1); Parathyroid Adenomatosis 1; G1/S-Specific Cyclin D1; BCL-1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein-A affinity chromatography |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | Protect from prolonged exposure to light. Do not freeze. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CCND1 |
| Gene Full Name | Cyclin D1 |
| Background | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019] |
| Function | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. |
| Cellular Localization | Cytoplasm, Membrane, Nucleus |
| Calculated MW | 34 kDa |
| PTM | Isopeptide bond; Phosphoprotein; Ubl conjugation |
Images (1) Click the Picture to Zoom In
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ARG43846 anti-Cyclin D1 antibody [DCS-6] (Biotin) FACS image
Flow Cytometry: MCF-7 stained with ARG43846 anti-Cyclin D1 antibody [DCS-6] (Biotin) at 5 μg/ml.
