Overview

Product Description	Rabbit Polyclonal antibody recognizes CtIP phospho (Thr847)
Tested Reactivity	Hu
Predict Reactivity	Ms, Bov, Chk, Dog, Goat, Gpig, Sheep
Tested Application	WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	CtIP
Antigen Species	Human
Immunogen	Synthetic phospho-peptide
Conjugation	Un-conjugated
Alternate Names	RBBP8; RB Binding Protein 8, Endonuclease; RIM; COM1; CTIP; Sporulation In The Absence Of SPO11 Protein 2 Homolog; Retinoblastoma-Binding Protein 8; Retinoblastoma Binding Protein 8; CTBP-Interacting Protein; DNA Endonuclease RBBP8; RBBP-8; SCKL2; CtIP; SAE2; Retinoblastoma-Interacting Protein And Myosin-Like; CtBP-Interacting Protein; Seckel Syndrome 2; EC 3.1.-.- ; JAWAD; JWDS

Application Instructions

Application Suggestion	Tested Application Dilution WB 1:1000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Antigen Affinity Purified
Buffer	10 mM HEPES (pH 7.5), 150 mM NaCl, 50% Glycerol and 100 µg/ml BSA.
Stabilizer	50% Glycerol and 100 µg/ml BSA
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.

Bioinformation

Database Links	GeneID: 5932 Human RBBP8 Swiss-port # Q99708 Human DNA endonuclease RBBP8
Gene Symbol	RBBP8
Gene Full Name	RB Binding Protein 8, Endonuclease
Background	The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Function	Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway.
Cellular Localization	Chromosome, Nucleus
Calculated MW	102 kDa
PTM	Isopeptide bond, Phosphoprotein, Ubl conjugation

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