ARG57107
anti-CtBP1 antibody [4D6]
anti-CtBP1 antibody [4D6] for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [4D6] recognizes CtBP1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 4D6 |
| Isotype | IgG2b, kappa |
| Target Name | CtBP1 |
| Antigen Species | Human |
| Immunogen | Recombinant fragment around aa. 1-440 of Human CtBP1 |
| Conjugation | Un-conjugated |
| Alternate Names | EC 1.1.1.-; CtBP1; BARS; C-terminal-binding protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 10% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CTBP1 |
| Gene Full Name | C-terminal binding protein 1 |
| Background | This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| Function | Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. [UniProt] |
| Calculated MW | 48 kDa |
| PTM | The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation. ADP-ribosylated; when cells are exposed to brefeldin A. Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4. |
Images (1) Click the Picture to Zoom In
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ARG57107 anti-CtBP1 antibody [4D6] WB image
Western blot: 40 µg of 1) HeLa, 2) NIH3T3, 3) 293T, 4) AGS, 5) Raji, 6) A549, and 7) Jurkat cell lysates stained with ARG57107 anti-CtBP1 antibody [4D6] at 1:500.
