ARG45598
anti-Crk p38 antibody
anti-Crk p38 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Crk p38 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Crk p38 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human Crk p38. |
| Conjugation | Un-conjugated |
| Alternate Names | CRK; CRK Proto-Oncogene, Adaptor Protein; V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog; Adapter Molecule Crk; Proto-Oncogene C-Crk; P38; V-Crk Sarcoma Virus CT10 Oncogene-Like Protein; CRKII |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.01% Sodium azide and 5% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CRK |
| Gene Full Name | CRK Proto-Oncogene, Adaptor Protein |
| Background | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008] |
| Function | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. [UniProt] |
| Cellular Localization | Cell membrane; Cytoplasm; Membrane. [UniProt] |
| Calculated MW | 34 kDa |
| PTM | Acetylation; Phosphoprotein. [UniProt] |
Images (6) Click the Picture to Zoom In
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ARG45598 anti-Crk p38 antibody IHC-P image
Immunohistochemistry: Human lung cancer stained with ARG45598 anti-Crk p38 antibody at 2 μg/ml dilution.
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ARG45598 anti-Crk p38 antibody WB image
Western blot: 293T stained with ARG45598 anti-Crk p38 antibody at 0.5 μg/ml dilution.
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ARG45598 anti-Crk p38 antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG45598 anti-Crk p38 antibody at 2 μg/ml dilution.
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ARG45598 anti-Crk p38 antibody WB image
Western blot: Rat liver stained with ARG45598 anti-Crk p38 antibody at 0.5 μg/ml dilution.
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ARG45598 anti-Crk p38 antibody IHC-P image
Immunohistochemistry: Mouse brain stained with ARG45598 anti-Crk p38 antibody at 2 μg/ml dilution.
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ARG45598 anti-Crk p38 antibody WB image
Western blot: Mouse liver stained with ARG45598 anti-Crk p38 antibody at 0.5 μg/ml dilution.
