ARG23544
anti-Complement C7 antibody [030-113.7.5.4]
anti-Complement C7 antibody [030-113.7.5.4] for ELISA,Functional study,Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [030-113.7.5.4] recognizes Complement C7. Mouse anti Human C7 antibody, clone 030-113.7.5.4 recognizes complement component 7 (C7), a 110 kDa glycoprotein present in the blood serum. The factor I domain of C7 binds the C terminus of the C5 alpha-chain, acting as a membrane anchor. This enables the assembly of the complement membrane attack complex (MAC) and consequent complement lytic activity. C7 deficiency is associated with increased susceptibility to recurrent infections, in particular by Neisseria meningitides. Mouse anti Human C7 antibody, clone 030-113.7.5.4 does not recognie membrane bound complement membrane attack complex. Mouse anti Human C7 antibody, clone 030-113.7.5.4 inhibits lysis of sensitised sheep erythrocytes.Removal of Sodium Azide is recommended prior to use in functional assays. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, FuncSt, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 030-113.7.5.4 |
| Isotype | IgG1 |
| Target Name | Complement C7 |
| Antigen Species | Human |
| Immunogen | Purified Human Complement C7. |
| Conjugation | Un-conjugated |
| Alternate Names | Complement component C7 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | BBS and 0.1% Sodium azide. |
| Preservative | 0.1% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | C7 |
| Gene Full Name | complement component 7 |
| Background | C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008] |
| Function | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. [UniProt] |
| Calculated MW | 94 kDa |
| PTM | C7 has 28 disulfide bridges. C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. [UniProt] |
