ARG43821
anti-Collagen I, alpha 1 antibody
anti-Collagen I, alpha 1 antibody for ICC/IF,Immunoprecipitation,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Collagen I, alpha 1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IP, WB |
| Specificity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Collagen I |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of human Collagen I. |
| Conjugation | Un-conjugated |
| Protein Full Name | Collagen alpha-1(I) chain |
| Alternate Names | COL1A1; Collagen Type I Alpha 1 Chain; OI4; Collagen, Type I, Alpha 1; Collagen Alpha-1(I) Chain; Alpha-1 Type I Collagen; Collagen Of Skin, Tendon And Bone, Alpha-1 Chain; Collagen Alpha-1(I) Chain Preproprotein; Type I Procollagen Alpha 1 Chain; Collagen Alpha 1 Chain Type I; Pro-Alpha-1 Collagen Type 1; Alpha1(I) Procollagen; Type I Proalpha 1; EDSARTH1; CAFYD; EDSC; OI1; OI2; OI3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 139 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | Tris-Glycine, 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | COL1A1 |
| Gene Full Name | Collagen Type I Alpha 1 Chain |
| Background | This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008] |
| Function | Type I collagen is a member of group I collagen (fibrillar forming collagen). [UniProt] |
| Cellular Localization | Extracellular matrix, Secreted. [UniProt] |
| Calculated MW | 139 kDa |
| PTM | Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein, Pyrrolidone carboxylic acid. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG43821 anti-Collagen I, alpha 1 antibody ICC/IF image
Immunofluorescence: Hela cells stained with ARG43821 anti-Collagen I, alpha 1 antibody at 1:50 dilution.
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ARG43821 anti-Collagen I, alpha 1 antibody WB image
Western blot: A549, HL-60 and U2OS cells stained with ARG43821 anti-Collagen I, alpha 1 antibody at 1:1000 dilution.
