ARG67081
anti-Claudin 6 antibody [SQab30353]
anti-Claudin 6 antibody [SQab30353] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Recombinant Rabbit Monoclonal antibody [SQab30353] recognizes Claudin 6 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30353 |
| Isotype | IgG |
| Target Name | Claudin 6 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Claudin 6. |
| Conjugation | Un-conjugated |
| Alternate Names | CLDN6; Claudin 6; Claudin-6; Skullin |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CLDN6 |
| Gene Full Name | Claudin 6 |
| Background | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16. |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space. |
| Cellular Localization | Cell junction, Cell membrane, Membrane, Tight junction |
| Calculated MW | 23 kDa |
| PTM | Phosphoprotein |
Images (1) Click the Picture to Zoom In
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ARG67081 anti-Claudin 6 antibody [SQab30353] HC-P image
Immunohistochemistry: Human ovarian cancer stained with ARG67081 anti-Claudin 6 antibody [SQab30353].
