ARG42692
anti-Carboxypeptidase B2 antibody
anti-Carboxypeptidase B2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Carboxypeptidase B2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Carboxypeptidase B2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to K166-D388 of Human Carboxypeptidase B2. |
| Conjugation | Un-conjugated |
| Alternate Names | Plasma carboxypeptidase B; Thrombin-activable fibrinolysis inhibitor; PCPB; Carboxypeptidase B2; TAFI; pCPB; EC 3.4.17.20; CPU; Carboxypeptidase U |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CPB2 |
| Gene Full Name | carboxypeptidase B2 (plasma) |
| Background | Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| Function | Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Calculated MW | 48 kDa |
| PTM | N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG42692 anti-Carboxypeptidase B2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG42692 anti-Carboxypeptidase B2 antibody at 1 µg/ml dilution.
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ARG42692 anti-Carboxypeptidase B2 antibody WB image
Western blot: Human placenta and HepG2 whole cell lysates stained with ARG42692 anti-Carboxypeptidase B2 antibody at 0.5 µg/ml dilution.
