ARG56499
anti-Calcium independent Phospholipase A2 antibody
anti-Calcium independent Phospholipase A2 antibody for Western blot and Human,Mouse,Rat,Bovine,Hamster
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Calcium independent Phospholipase A2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Bov, Hm |
| Tested Application | WB |
| Specificity | This antibody does not react to cPLA2 and sPLA2. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Calcium independent Phospholipase A2 |
| Antigen Species | Hamster |
| Immunogen | Synthetic peptide corresponding to aa. 557-576 of Hamster Calcium-independent Phospholipase A2. (PRFNQNINLKPPTQPADQLV) |
| Conjugation | Un-conjugated |
| Alternate Names | Intracellular membrane-associated calcium-independent phospholipase A2 beta; NBIA2; GVI; iPLA2; IPLA2-VIA; NBIA2B; PLA2; NBIA2A; INAD1; Patatin-like phospholipase domain-containing protein 9; 85/88 kDa calcium-independent phospholipase A2; EC 3.1.1.4; iPLA2-beta; GVI PLA2; PARK14; PNPLA9; iPLA2beta; Group VI phospholipase A2; CaI-PLA2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Pla2g6 |
| Gene Full Name | phospholipase A2 group VI |
| Background | The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010] |
| Function | Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity. [UniProt] |
| Calculated MW | 90 kDa |
Images (1) Click the Picture to Zoom In
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ARG56499 anti-Calcium independent Phospholipase A2 antibody WB image
Western blot: 1) 30 µg of CHO cell lysate, and 2) 50 µg of COS-1 cell lysate stained with ARG56499 anti-Calcium independent Phospholipase A2 antibody.
